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VEGFB
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Belongs to the PDGF/VEGF growth factor family. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 11q13.1 |
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Cellular Component:
extracellular region; extracellular space; membrane; platelet alpha granule lumen
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Molecular Function:
chemoattractant activity; growth factor activity; heparin binding; identical protein binding; protein binding; vascular endothelial growth factor receptor 1 binding
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Biological Process:
cardiac muscle contraction; coronary vasculature development; induction of positive chemotaxis; positive chemotaxis; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of endothelial cell proliferation; positive regulation of mast cell chemotaxis; positive regulation of protein phosphorylation; protein O-linked glycosylation; response to hypoxia; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway
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Reference #:
P49765
(UniProtKB)
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Alt. Names/Synonyms: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VEGFB; VEGFL; VRF
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Gene Symbols: VEGFB
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Molecular weight:
21,602 Da
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Basal Isoelectric point:
8.46
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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