GALNTL2 Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase; Vesicle
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component:  Golgi membrane; integral component of membrane; transport vesicle
Molecular Function:  carbohydrate binding; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity
Biological Process:  O-glycan processing
Reference #:  Q8N3T1 (UniProtKB)
Alt. Names/Synonyms: DKFZp686H1113; GalNAc-T-like protein 2; GALNACT15; GALNT13; GALNT15; GALNT7; GALNTL2; GLT15; GLTL2; PIH5; polypeptide GalNAc transferase 15; Polypeptide GalNAc transferase-like protein 2; polypeptide N-acetylgalactosaminyltransferase 13; Polypeptide N-acetylgalactosaminyltransferase 15; Polypeptide N-acetylgalactosaminyltransferase-like protein 2; pp-GalNAc-T15; pp-GaNTase-like protein 2; pregnancy-induced hypertension syndrome-related protein 5; Protein-UDP acetylgalactosaminyltransferase-like protein 2; UDP-GalNAc transferase T15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
Gene Symbols: GALNT15
Molecular weight: 73,063 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB