ITGB7 Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. Belongs to the integrin beta chain family. Expressed in a variety of leukocyte lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cell surface; integrin alpha4-beta7 complex; plasma membrane; receptor complex
Molecular Function:  cell adhesion molecule binding; metal ion binding; protein binding; signaling receptor activity; virus receptor activity
Biological Process:  cell adhesion; cell-matrix adhesion; cell-matrix adhesion involved in ameboidal cell migration; extracellular matrix organization; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte tethering or rolling; receptor clustering; regulation of immune response; substrate adhesion-dependent cell spreading; T cell migration; viral entry into host cell
Reference #:  P26010 (UniProtKB)
Alt. Names/Synonyms: Gut homing receptor beta subunit; integrin beta 7 subunit; Integrin beta-7; integrin subunit beta 7; integrin, beta 7; ITB7; ITGB7
Gene Symbols: ITGB7
Molecular weight: 86,903 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene