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ZNF653
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. Belongs to the krueppel C2H2-type zinc-finger protein family. Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Nuclear receptor co-regulator |
| Chromosomal Location of mouse Ortholog: 9|9 A3 |
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Cellular Component:
nucleus
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Molecular Function:
AF-2 domain binding; DNA binding; DNA-binding transcription factor binding; metal ion binding; transcription coregulator activity; transcription corepressor activity
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Biological Process:
extracellular negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Reference #:
Q6YND2
(UniProtKB)
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Alt. Names/Synonyms: 67 kDa zinc finger protein; E430039K05Rik; Zfp653; Zinc finger protein 653; Zinc finger protein Zip67; Zip67; ZN653; Znf653
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Gene Symbols: Znf653
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Molecular weight:
67,517 Da
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Basal Isoelectric point:
6.61
Predict pI for various phosphorylation states
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