SCUBE3 Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component:  cell surface; plasma membrane
Molecular Function:  calcium ion binding; protein binding
Biological Process:  extracellular matrix disassembly; positive regulation of smoothened signaling pathway; protein heterooligomerization; protein homooligomerization
Reference #:  Q8IX30 (UniProtKB)
Alt. Names/Synonyms: CEGF3; CUB and EGF containing protein 3; CUB domain and EGF-like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; SCUB3; SCUBE3; signal peptide, CUB and EGF-like domain containing protein 3; Signal peptide, CUB and EGF-like domain-containing protein 3; signal peptide, CUB domain, EGF-like 3
Gene Symbols: SCUBE3
Molecular weight: 109,282 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene