TNNI2 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  cytosol; nucleus; troponin complex
Molecular Function:  protein binding; troponin T binding
Biological Process:  muscle filament sliding; positive regulation of transcription, DNA-templated; regulation of muscle contraction; skeletal muscle contraction
Disease: Arthrogryposis, Distal, Type 2b
Reference #:  P48788 (UniProtKB)
Alt. Names/Synonyms: AMCD2B; DA2B; DA2B1; fast-twitch skeletal muscle troponin I; FSSV; fsTnI; TNNI2; troponin I fast twitch 2; troponin I type 2 (skeletal, fast); Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast; troponin I2, fast skeletal type
Gene Symbols: TNNI2
Molecular weight: 21,339 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
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TNNI2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB