GFRAL Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. Belongs to the GDNFR family. Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component:  external side of plasma membrane; integral component of membrane
Molecular Function:  glial cell-derived neurotrophic factor receptor activity; protein binding; receptor tyrosine kinase binding
Biological Process:  activation of MAPK activity; glial cell-derived neurotrophic factor receptor signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; positive regulation of MAPK cascade; positive regulation of protein kinase B signaling; reduction of food intake in response to dietary excess; stress-activated protein kinase signaling cascade
Reference #:  Q6UXV0 (UniProtKB)
Alt. Names/Synonyms: bA360D14.1; C6orf144; GDNF family receptor alpha like; GDNF family receptor alpha-like; GFRAL; GRAL; IVFI9356; UNQ9356
Gene Symbols: GFRAL
Molecular weight: 44,518 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene