|
N6AMT1
Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT. Belongs to the eukaryotic/archaeal PrmC-related family. Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.1.1.-; Methyltransferase |
| Chromosomal Location of human Ortholog: 21q21.3 |
|
Cellular Component:
cytosol; eRF1 methyltransferase complex; nucleus; protein-containing complex
|
|
Molecular Function:
histone lysine N-methyltransferase activity; methylarsonite methyltransferase activity; nucleic acid binding; protein binding; protein methyltransferase activity; protein-glutamine N-methyltransferase activity; S-adenosyl-L-methionine binding; S-adenosylmethionine-dependent methyltransferase activity; site-specific DNA-methyltransferase (adenine-specific) activity
|
|
Biological Process:
arsonoacetate metabolic process; chromatin organization; DNA methylation on adenine; histone lysine methylation; methylation; peptidyl-glutamine methylation; positive regulation of cell growth; toxin metabolic process
|
|
Reference #:
Q9Y5N5
(UniProtKB)
|
|
Alt. Names/Synonyms: C21orf127; HemK methyltransferase family member 2; HEMK2; KMT9; Lysine N-methyltransferase 9; M.HsaHemK2P; Methylarsonite methyltransferase N6AMT1; Methyltransferase N6AMT1; MGC19995; MTQ2; N(6)-adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1 (putative); N6-DNA-methyltransferase; N6AMT; N6AMT1; N6MT1; PRED28; PrmC; Protein N(5)-glutamine methyltransferase
|
|
Gene Symbols: N6AMT1
|
|
Molecular weight:
22,957 Da
|
|
Basal Isoelectric point:
5.02
Predict pI for various phosphorylation states
|
