N6AMT1 Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT. Belongs to the eukaryotic/archaeal PrmC-related family. Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.-; Methyltransferase
Chromosomal Location of human Ortholog: 21q21.3
Cellular Component:  cytosol; eRF1 methyltransferase complex; nucleus; protein-containing complex
Molecular Function:  histone lysine N-methyltransferase activity; methylarsonite methyltransferase activity; nucleic acid binding; protein binding; protein methyltransferase activity; protein-glutamine N-methyltransferase activity; S-adenosyl-L-methionine binding; S-adenosylmethionine-dependent methyltransferase activity; site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process:  arsonoacetate metabolic process; chromatin organization; DNA methylation on adenine; histone lysine methylation; methylation; peptidyl-glutamine methylation; positive regulation of cell growth; toxin metabolic process
Reference #:  Q9Y5N5 (UniProtKB)
Alt. Names/Synonyms: C21orf127; HemK methyltransferase family member 2; HEMK2; KMT9; Lysine N-methyltransferase 9; M.HsaHemK2P; Methylarsonite methyltransferase N6AMT1; Methyltransferase N6AMT1; MGC19995; MTQ2; N(6)-adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1; N-6 adenine-specific DNA methyltransferase 1 (putative); N6-DNA-methyltransferase; N6AMT; N6AMT1; N6MT1; PRED28; PrmC; Protein N(5)-glutamine methyltransferase
Gene Symbols: N6AMT1
Molecular weight: 22,957 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB