PRMT7 Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.125; EC 2.1.1.126; Methyltransferase; Methyltransferase, protein arginine; RNA processing
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  cytosol; fibrillar center; nucleoplasm; nucleus
Molecular Function:  [myelin basic protein]-arginine N-methyltransferase activity; histone binding; histone methyltransferase activity (H4-R3 specific); histone-arginine N-methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein complex binding; S-adenosylmethionine-dependent methyltransferase activity
Biological Process:  cell differentiation; DNA methylation involved in gamete generation; histone arginine methylation; histone H4-R3 methylation; histone methylation; peptidyl-arginine methylation; peptidyl-arginine methylation, to symmetrical-dimethyl arginine; regulation of gene expression by genetic imprinting; regulation of protein binding; spliceosomal snRNP assembly
Disease: Short Stature, Brachydactyly, Intellectual Developmental Disability, And Seizures
Reference #:  Q9NVM4 (UniProtKB)
Alt. Names/Synonyms: [Myelin basic protein]-arginine N-methyltransferase PRMT7; ANM7; FLJ10640; Histone-arginine N-methyltransferase PRMT7; KIAA1933; myelin basic protein-arginine N-methyltransferase; PRMT7; protein arginine methyltransferase 7; Protein arginine N-methyltransferase 7; SBIDDS
Gene Symbols: PRMT7
Molecular weight: 78,459 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PRMT7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene