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KHDRBS1
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4. Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. Belongs to the KHDRBS family. Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 1p35.2 |
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Cellular Component:
cytoplasm; cytosol; Grb2-Sos complex; membrane; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
DNA binding; identical protein binding; mRNA binding; poly(A) binding; poly(U) RNA binding; protein binding; protein domain specific binding; protein tyrosine kinase binding; protein-containing complex binding; RNA binding; SH2 domain binding; SH3 domain binding; signaling adaptor activity
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Biological Process:
G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; mRNA processing; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of RNA export from nucleus; positive regulation of translational initiation; regulation of alternative mRNA splicing, via spliceosome; regulation of protein stability; regulation of RNA export from nucleus; spermatogenesis; T cell receptor signaling pathway
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Reference #:
Q07666
(UniProtKB)
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Alt. Names/Synonyms: FLJ34027; GAP-associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62 (Sam68); KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH RNA binding domain containing, signal transduction associated 1; KHDR1; KHDRBS1; p21 Ras GTPase-activating protein-associated p62; p62; p68; SAM68; Src-associated in mitosis 68 kDa protein
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Gene Symbols: KHDRBS1
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Molecular weight:
48,227 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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