STX1A iso2
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1). Belongs to the syntaxin family. Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Vesicle |
Chromosomal Location of human Ortholog: 7q11.23 |
Cellular Component:
axon; cytosol; endomembrane system; extracellular region; neuron projection; nuclear membrane; plasma membrane; presynaptic active zone membrane; SNARE complex; synaptic vesicle; synaptic vesicle membrane; synaptobrevin 2-SNAP-25-syntaxin-1a complex
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Molecular Function:
calcium channel inhibitor activity; chloride channel inhibitor activity; identical protein binding; kinase binding; protein binding; SNAP receptor activity; SNARE binding
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Biological Process:
calcium-ion regulated exocytosis; exocytosis; insulin secretion; intracellular protein transport; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of excitatory postsynaptic potential; positive regulation of neurotransmitter secretion; positive regulation of norepinephrine secretion; protein sumoylation; regulation of insulin secretion; regulation of synaptic vesicle priming; secretion by cell; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; vesicle docking
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Reference #:
Q16623-2
(UniProtKB)
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Alt. Names/Synonyms: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; STX1A; STX1A iso2; SYN1A; syntaxin 1A; syntaxin 1A (brain); Syntaxin-1A
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Gene Symbols: STX1A
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Molecular weight:
29,632 Da
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Basal Isoelectric point:
4.83
Predict pI for various phosphorylation states
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