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CYREN
Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only. Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown. May act as a regulator of proteasome. Isoform 4: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only. Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 7q33 |
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Cellular Component:
cytoplasm; nucleus; site of double-strand break
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Molecular Function:
protein binding
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Biological Process:
double-strand break repair via nonhomologous end joining; immunoglobulin V(D)J recombination; negative regulation of double-strand break repair via nonhomologous end joining
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Reference #:
Q9BWK5
(UniProtKB)
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Alt. Names/Synonyms: C7orf49; Cell cycle regulator of NHEJ; Cell cycle regulator of non-homologous end joining; chromosome 7 open reading frame 49; CYREN; FLJ22450; FLJ27285; MGC5242; Modulator of retrovirus infection homolog; MRI; MRI-2
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Gene Symbols: CYREN
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Molecular weight:
16,829 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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