MyoD Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA splicing; Transcription factor
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component:  cytosol; myofibril; nuclear body; nuclear chromatin; nucleoplasm; transcription factor complex
Molecular Function:  chromatin binding; chromatin DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; nuclear hormone receptor binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; transcription coactivator activity; ubiquitin protein ligase binding
Biological Process:  cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; cellular response to oxygen levels; cellular response to starvation; cellular response to tumor necrosis factor; histone H3 acetylation; histone H4 acetylation; muscle cell fate commitment; muscle organ development; myoblast fate determination; myoblast fusion; myotube cell development; myotube differentiation involved in skeletal muscle regeneration; negative regulation of myoblast proliferation; positive regulation of muscle cell differentiation; positive regulation of myoblast fusion; positive regulation of skeletal muscle tissue regeneration; positive regulation of snRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing; regulation of transcription by RNA polymerase II; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle tissue development
Disease: Myopathy, Congenital, With Diaphragmatic Defects, Respiratory Insufficiency, And Dysmorphic Facies
Reference #:  P15172 (UniProtKB)
Alt. Names/Synonyms: BHLHC1; Class C basic helix-loop-helix protein 1; Myf-3; MYF3; Myoblast determination protein 1; MYOD; MYOD1; MYODRIF; myogenic differentiation 1; Myogenic factor 3; PUM
Gene Symbols: MYOD1
Molecular weight: 34,501 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein