MyoD a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA splicing; Transcription factor
Chromosomal Location of Human Ortholog: 7 B3|7 30.03 cM
Cellular Component:  cytoplasm; cytosol; myofibril; nuclear body; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  chromatin binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; enzyme binding; nuclear hormone receptor binding; promoter-specific chromatin binding; protein binding; protein dimerization activity; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  cardiac muscle cell differentiation; cell differentiation; cellular response to estradiol stimulus; cellular response to glucocorticoid stimulus; cellular response to oxygen levels; cellular response to starvation; cellular response to tumor necrosis factor; multicellular organism development; muscle organ development; myoblast differentiation; myoblast fate determination; myoblast fusion; myotube cell development; myotube differentiation; myotube differentiation involved in skeletal muscle regeneration; negative regulation of myoblast proliferation; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of skeletal muscle tissue regeneration; positive regulation of snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of alternative mRNA splicing, via spliceosome; regulation of gene expression; regulation of RNA splicing; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle tissue development; skeletal muscle tissue regeneration; striated muscle cell differentiation; transcription, DNA-dependent
Reference #:  P10085 (UniProtKB)
Alt. Names/Synonyms: AI503393; bHLHc1; MYF3; Myoblast determination protein 1; Myod; Myod-1; Myod1; myogenic differentiation 1
Gene Symbols: Myod1
Molecular weight: 34,233 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
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MyoD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene