H4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H4 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Cellular Component: 
Reference #:  NP_001139343 (RefSeq)
Alt. Names/Synonyms: germinal histone H4-like; H4; H4 histone 16; H4F2; HIST; Histone H4
Gene Symbols: H4-16
Molecular weight: 11,236 Da
Basal Isoelectric point: 11.36  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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H4

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept