H4
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H4 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Cellular Component:
Reference #:
NP_001139343
(RefSeq)
Alt. Names/Synonyms: germinal histone H4-like; H4; H4 histone 16; H4F2; HIST; Histone H4
Gene Symbols: H4-16
Molecular weight:
11,236 Da
Basal Isoelectric point:
11.36
Predict pI for various phosphorylation states
CST Pathways:
Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
Select Structure to View Below
H4
1KX4 - F/B=1-102 (human)
1KX5 - F/B=1-102 (human)
1M18 - F/B=1-102 (human)
1M19 - F/B=1-102 (human)
1M1A - F/B=1-102 (human)
1S32 - F/B=1-102 (human)
1ZKK - A/B/C/D=231-393 (human)
2BQZ - A/E=233-393 (human)
2CV5 - B/F=1-103 (human)
2IG0 - A=1484-1603 (human)
2KWN - A=261-372 (human)
2KWO - A=261-372 (human)
2LVM - B=15-28 (human)
2QQS - A/B=897-1011 (human)
2RJE - A/B/C=200-530 (human)
2RNY - B=14-28 (human)
2RS9 - A=2-11 (human)
3A6N - B/F=1-103 (human)
3AFA - B/F=1-103 (human)
3AN2 - C/G=1-130 (human)
3AV1 - B/F=1-103 (human)
3AV2 - B/F=1-103 (human)
3AYW - B/F=1-103 (human)
3AZE - B/F=1-103 (human)
3AZF - B/F=1-103 (human)
3AZG - B/F=1-103 (human)
3AZH - B/F=1-103 (human)
3AZI - B/F=1-103 (human)
3AZJ - B/F=1-103 (human)
3AZK - B/F=1-103 (human)
3AZL - B/F=1-103 (human)
3AZM - B/F=1-103 (human)
3AZN - B/F=1-103 (human)
3CFS - E=28-42 (human)
3CFV - E/F=25-42 (human)
3F9W - E/F/G/H=16-25 (human)
3F9X - E/F/G/H=16-25 (human)
3F9Y - E/F=16-25 (human)
3F9Z - E/F/G/H=16-25 (human)
3IJ1 - A=77-441 (human)
3JPX - A=40-441 (human)
3NQJ - B=21-103 (human)
3NQU - B=1-103 (human)
3O36 - D/E=15-20 (human)
3QBY - A/C/B=1-93 (human)
3QZS - C/D=13-22 (human)
3QZT - B=13-22 (human)
3QZV - C=8-18 (human)
3R45 - B=1-103 (human)
3UVW - B=2-12 (human)
3UVX - A=44-168 (human)
3UVY - B=16-26 (human)
3UW9 - E/F=8-18 (human)
3W96 - B/F=1-103 (human)
3W97 - B/F=1-103 (human)
3W98 - B/F=1-103 (human)
3W99 - B/F=17-103 (human)
3WA9 - B/F=1-103 (human)
3WAA - B/F=1-103 (human)
3WKJ - B/F=1-103 (human)
3WTP - F/B=1-103 (human)
3X1S - F/B=2-103 (human)
3X1T - F/B=2-103 (human)
3X1U - F/B=2-103 (human)
3X1V - F/B=2-103 (human)
4GQB - C=2-22 (human)
4H9N - B=2-103 (human)
4H9O - B=2-103 (human)
4H9P - B=2-103 (human)
4H9Q - B=2-103 (human)
4H9R - B=2-103 (human)
4H9S - C/D=21-103 (human)
4HGA - C=1-103 (human)
4M38 - F/E=2-22 (human)
4N3W - A=1080-1316 (human)
4N4F - A=1080-1316 (human)
4QUT - B=7-13 (human)
4QUU - B=1-13 (human)
4QYD - B=5-18 (human)
4U9W - A/D/C/B=17-220 (human)
4YM5 - F/B=1-103 (human)
4YM6 - F/B=1-103 (human)
4YY6 - Z=2-12 (human)
4YYD - Z=2-12 (human)
4YYG - B=2-12 (human)
4YYH - Z/Y=2-12 (human)
4YYI - F/C=2-12 (human)
4YYJ - F/C=2-12 (human)
4YYK - F/C=2-12 (human)
4YYM - Z=2-12 (human)
4YYN - Z=2-12 (human)
4Z2M - H/J=1-103 (human)
4Z5T - F/B=1-103 (human)
5AV5 - F/B=1-103 (human)
5AV6 - F/B=1-103 (human)
5AV8 - F/B=1-103 (human)
5AV9 - F/B=1-103 (human)
5AVB - F/B=1-103 (human)
5AVC - F/B=1-103 (human)
5AY8 - F/B=1-103 (human)
5B0Y - F/B=1-103 (human)
5B0Z - F/B=1-103 (human)
5B24 - F/B=1-103 (human)
5B2I - F/B=1-103 (human)
5B2J - F/B=1-103 (human)
5B31 - F/B=1-103 (human)
5B32 - F/B=1-103 (human)
5B33 - F/B=1-103 (human)
5B40 - F/B=1-103 (human)
5BNV - E/B=2-103 (human)
5BNX - B=2-103 (human)
5BO0 - B=2-103 (human)
5C3I - S/O/W/C/K/G=1-103 (human)
5CPI - F/B=1-103 (human)
5CPJ - F/B=1-103 (human)
5CPK - F/B=1-103 (human)
5FA5 - C=2-21 (human)
5FFW - A/B=626-740 (human)
5FWE - D/C=2-16 (human)
5GSE - F/P/L/B=1-103 (human)
5GSU - F/B=2-103 (human)
5GT0 - F/B=2-103 (human)
5GT3 - F/B=2-103 (human)
5GTC - F/B=1-103 (human)
5GXQ - F/B=1-103 (human)
5JA4 - B=2-103 (human)
5JRG - F/B=1-103 (human)
5KDM - B=2-103 (human)
5TEG - A/B=234-393 (human)
5X7X - F/B=1-103 (human)
5XF3 - F/B=1-103 (human)
5XF4 - F/B=1-103 (human)
5XF5 - F/B=1-103 (human)
5Y0C - H/D=1-126 (human)
5Y0D - H/D=1-126 (human)
5YE3 - C=2-13 (human)
5YE4 - E/F=2-13 (human)
5Z23 - C/G=1-130 (human)
5Z30 - C/G=1-128 (human)
5ZBX - C/G=1-130 (human)
5ZGC - F/A/D/C/E/B=121-394 (human)
6A5L - b/f=1-103 (human)
6A5O - b/f=1-103 (human)
6A5P - b/f=1-103 (human)
6A5R - b/f=1-103 (human)
6A5T - b/f=1-103 (human)
6A5U - b/f=1-103 (human)
6A5V - b/f=1-103 (human)
6ACP - A=36-302 (human)
6BUZ - F/B=1-103 (human)
6C0W - F/B=1-102 (human)
6E0C - C/G=1-130 (human)
6E0P - C/G=1-130 (human)
6ETX - O/K=1-130 (human)
6FML - Q/M=2-136 (human)
6HKT - F/P/v/B/V/l/Z/p/b/z/f/L=1-103 (human)
6HTS - F/D/B=1-463 (human)
6INQ - h/d=1-126 (human)
6IPU - C/G=14-120 (human)
6IQ4 - C/G=15-120 (human)
6IR9 - h/d=1-126 (human)
6J4W - h/d=1-126 (human)
6J4X - h/d=1-126 (human)
6J4Y - h/d=1-126 (human)
6J4Z - h/d=1-126 (human)
6J50 - h/d=1-126 (human)
6J51 - h/d=1-126 (human)
6JOU - C/G=1-128 (human)
6JR0 - C/G=1-130 (human)
6JR1 - C/G=1-130 (human)
6JXD - C/G=14-119 (human)
6K1I - H/D=1-126 (human)
6K1J - H/D=1-126 (human)
6K1K - H/D=1-126 (human)
6KE9 - C/G=15-119 (human)
6KVD - H/D=1-126 (human)
6KXV - C/G=1-130 (human)
6L49 - Q/M/C/G/Y/U=1-130 (human)
6L4A - Q/M/C/G/Y/U=1-130 (human)
6L9H - C/G=15-119 (human)
6L9Z - B/F/L/P=1-103 (human)
6LA2 - B/F/L/P/V/Z/f/j=1-103 (human)
6LA8 - S=1-194 (human)
6LA9 - S/T=1-194 (human)
6LAB - B/F/L/P=1-103 (human)
6LE9 - C/G=15-119 (human)
6LER - B/F/L/P=1-103 (human)
6M3V - Q/M/C/G=1-130 (human)
6M44 - Q/M/C/G=1-130 (human)
6M4D - C/G=1-114 (human)
6M4G - F/B=1-103 (human)
6M4H - F/B=1-103 (human)
6MLC - F/E=2-21 (human)
6MUO - M=1-212 (human)
6MUP - M/N=1-212 (human)
6O1D - H/D=1-126 (human)
6R0C - C/G=1-130 (human)
6R8Y - F/B=1-103 (human)
6R8Z - F/B=1-103 (human)
6R90 - F/B=1-103 (human)
6R91 - F/B=1-103 (human)
6R92 - F/B=1-103 (human)
6R93 - F/B=1-103 (human)
6R94 - F/B=1-103 (human)
6RNY - C/G=1-130 (human)
6RXS - B=13-23 (human)
6SE0 - F/B=1-103 (human)
6SE6 - F/B=1-103 (human)
6SEE - F/B=1-103 (human)
6SEF - F/B=1-103 (human)
6SEG - F/B=1-103 (human)
6T79 - C/G=1-130 (human)
6T7A - C/G=1-130 (human)
6T7B - C/G=1-130 (human)
6T7C - C/G=1-130 (human)
6T7D - C/G=1-130 (human)
6T90 - C/G=1-130 (human)
6T93 - C/G=1-130 (human)
6UHD - D/C=2-21 (human)
6UPK - A/E=1-136 (human)
6UPL - A/E=1-136 (human)
6USJ - H/N/D/R=1-126 (human)
6V2K - H/D=1-126 (human)
6V92 - e/a=1-136 (human)
6VO5 - D/C=2-21 (human)
6X59 - K=142-507 (human)
6X5A - K=142-507 (human)
6XJD - K/L=142-507 (human)
6Y5D - F/N/R/B=1-103 (human)
6Y5E - C=12-118 G=12-119 (human)
6YOV - C/G=1-130 (human)
7A08 - e/i=2-103 (human)
7BWD - L/M=1-76 (human)
7BXT - B/F=2-103 (human)
7BY0 - B/F=1-102 (human)
7C0M - F/b/f/B=2-103 (human)
7CCQ - K=157-522 (human)
7CCR - K/V=157-522 (human)
7CIZ - C/G/K=61-130 (human)
7CJ0 - G/H=61-130 (human)
7COW - B/F/L/P=1-103 (human)
7D1Z - K=45-393 (human)
7D20 - K=45-393 (human)
7DBP - B/F=1-103 (human)
7E8D - K=973-1226 (human)
7EIC - C=2-13 (human)
7EID - A/B=1-138 (human)
7JO9 - F/B=1-103 (human)
7JOA - F/B=1-103 (human)
7JZV - A=2-147 (human)
7K5X - F/B=1-103 (human)
7K5Y - F/B=1-103 (human)
7K60 - F/B=1-103 (human)
7K61 - F/B=1-103 (human)
7K63 - F/B=1-103 (human)
7LMK - F/G/H/I=15-27 (human)
7LMM - F/G/H/I=15-27 (human)
7LYA - B/F=1-103 (human)
7LYB - P=2-147 (human)
7LYC - K=1-76 (human)
7M98 - B=2-16 (human)
7NL0 - B/F=1-103 (human)
7PET - B/F/L/P/b/f/l/p=1-103 (human)
7PEU - B/F/L/P/b/f=1-103 (human)
7PEV - B/F/L/P=1-103 (human)
7PEW - B/F=1-103 (human)
7PEX - b/f=1-103 (human)
7PEY - L/P=1-103 (human)
7PEZ - l/p=1-103 (human)
7PF0 - B/F/L/P/b/f=1-103 (human)
7PF2 - B/F/L/P=1-103 (human)
7PF3 - l/p=1-103 (human)
7PF4 - L/P=1-103 (human)
7PF5 - b/f=1-103 (human)
7PF6 - B/F=1-103 (human)
7PFA - B/F/L/P/b/f=1-103 (human)
7PFC - B/F/L/P=1-103 (human)
7PFD - B/F=1-103 (human)
7PFE - b/f=1-103 (human)
7PFF - L/P=1-103 (human)
7PFT - B/F/L/P/b/f=1-103 (human)
7PFU - B/F/L/P=1-103 (human)
7PFV - B/F=1-103 (human)
7PFW - b/f=1-103 (human)
7PFX - L/P=1-103 (human)
7PII - B/F=1-103 (human)
7R5R - B/F=1-103 (human)
7SCY - K=385-492 (human)
7SCZ - K=385-492 (human)
7TAN - K/L=1-396 (human)
7U0G - K/L/M=138-290 (human)
7U0I - L/M=138-292 (human)
7U0J - B/F=1-103 (human)
7U46 - B/F=1-103 (human)
7U47 - B/F/M/Q=1-103 (human)
7U4D - B/F/M/Q=1-103 (human)
7U50 - B/F=2-103 (human)
7U51 - B/F=2-103 (human)
7U52 - B/F=2-103 (human)
7U53 - B/F=2-103 (human)
7UV9 - K=2-685 (human)
7V1M - G/H=499-662 (human)
7V6Q - D/H=454-659 (human)
7V90 - B/F=1-103 (human)
7V96 - B/F/L/P=1-103 (human)
7V9C - B/F/L/P=1-103 (human)
7V9J - B/F/L/P/T/X=1-103 (human)
7V9K - B/F/L/P/T/X/b/f=1-103 (human)
7V9S - B/F/L/P/T/X=1-103 (human)
7VA4 - B/F/L/P/T/X/b/f=1-103 (human)
7VCQ - B/E/H=1-103 (human)
7VZ4 - B/F=2-103 (human)
7W9V - B/F=1-103 (human)
7WBV - b/f=2-103 (human)
7WBW - b/f=2-103 (human)
7WBX - b/f=2-103 (human)
7X57 - B/D/F/H=1-103 (human)
7X58 - B/D/F/H=2-103 (human)
7XCR - L=1-76 (human)
7XCT - L/N=1-76 (human)
7XD0 - K/L=1-76 (human)
7XD1 - D/H=32-125 (human)
7XVL - B/F/L/P/V/Z/f/j=1-103 (human)
7XVM - B/F/L/P=1-103 (human)
7XX5 - B/F/L/P=1-103 (human)
7XX6 - B/F/L/P/V/Z/f/j=1-103 (human)
7XX7 - B/F/L/P=1-103 (human)
7XZX - K/L/M/N=94-293 (human)
7XZY - B/F=1-103 (human)
7XZZ - K/L/M/N=1-393 (human)
7Y00 - B/F=1-103 (human)
7Y5U - C=1-425 (human)
7Y5V - C/H=1-425 (human)
7Y5W - B/D/F/H=1-103 (human)
7Y60 - B/D/F/H=1-103 (human)
7Y61 - B/D/F/H=1-103 (human)
7Y7I - B/F=1-103 (human)
7YOZ - B/D/F/H=1-103 (human)
7YQK - A/E=37-136 (human)
7YRD - B/F=2-103 (human)
7YWX - B/F=1-103 (human)
7YYH - B/F=1-103 (human)
8AAG - B/F=1-103 (human)
8ATF - N/R=2-103 (human)
8AV6 - N/R=2-103 (human)
8DK5 - B/F=1-103 (human)
8EVG - B/F=1-103 (human)
8EVH - B/F=1-103 (human)
8EVI - B/F=1-103 (human)
8EVJ - B/F=1-103 (human)
8GUI - B/F=2-103 (human)
8GUJ - B/F=2-103 (human)
8GUK - B/F=2-103 (human)
8H0V - b/f=1-103 (human)
8H0W - b/f=1-103 (human)
8H1T - M=153-228 (human)
8HE5 - b/f=1-103 (human)
8HLW - A=119-399 (human)
8IEG - F/L=23-102 (human)
8IEJ - R=1-150 (human)
8IHL - B/F/L/N/R/V=1-103 (human)
8IQF - C/H=1-425 (human)
8IQG - C=1-425 (human)
8J6S - B/D/F/H=1-103 (human)
8J6T - B/D/F/H=1-103 (human)
8JBX - B/F=2-103 (human)
8JCC - B/F=2-103 (human)
8JCD - B/F=2-103 (human)
8JH2 - b/f=1-103 (human)
8JH3 - b/f=1-103 (human)
8JH4 - b/f=1-103 (human)
8JHF - K=1-361 (human)
8JHG - K=1-361 (human)
8JL9 - B/F=1-103 (human)
8JLA - B/F=17-103 (human)
8JLB - B/F=1-103 (human)
8JLD - B/F=1-103 (human)
8JND - K/L/M/N/O/P/Q/R/S=1-339 (human)
8JNE - K/L/M/N/O/P/Q/R/S/T=1-339 (human)
8KB5 - B/F=1-103 (human)
8OL1 - L=83-326 (human)
8OOA - N/R=2-103 (human)
8OOS - N/R=2-103 (human)
8OSJ - M=26-395 (human)
8OSK - M=26-395 (human)
8OSL - M/O=26-395 (human)
8OTS - K=1-273 (human)
8OTT - G=11-118 (human)
8OX0 - B/F=1-103 (human)
8OX1 - L/M=1-439 (human)
8PEF - A=802-934 (human)
8QZM - B/F=2-103 (human)
8SB6 - D/E=2-16 (human)
8SMW - L=1-147 (human)
8SMX - L=1-147 (human)
8SMY - L=1-147 (human)
8SMZ - L=1-147 (human)
8SN0 - L=1-147 (human)
8SN1 - L=1-147 (human)
8SN2 - L=1-147 (human)
8SN3 - M=170-228 (human)
8SN4 - M=170-228 (human)
8SN5 - M=170-228 (human)
8SN6 - M=170-228 (human)
8SN7 - M=170-228 (human)
8SN8 - M=170-228 (human)
8SN9 - M=170-228 (human)
8SNA - M=170-228 (human)
8SPS - L/M=138-290 (human)
8SPU - L=138-290 (human)
8SYP - B/F=1-103 (human)
8TGP - A=34-356 (human)
8TXV - M=170-228 (human)
8TXW - M=170-228 (human)
8TXX - M=170-228 (human)
8U13 - K=1-94 (human)
8U14 - L=2-147 (human)
8UPF - L=2-147 (human)
8VFX - B/F=1-103 (human)
8VFY - B/F=1-103 (human)
8VFZ - B/F=1-103 (human)
8VG0 - B/F=1-103 (human)
8VG1 - B/F=1-103 (human)
8VG2 - B/F=1-103 (human)
8VWS - B/F=2-103 (human)
8VWT - K=1-345 (human)
8VWU - B/F=2-103 (human)
8VWV - K=1-345 (human)
8W9D - b/f=1-103 (human)
8W9E - b/f=1-103 (human)
8W9F - b/f=1-103 (human)
8WG5 - M=1-823 (human)
8X7I - K=1-147 (human)
8X7J - K=1-147 (human)
8X7K - K=1-147 (human)
8XBT - K/L/M/N/O/P/Q/R=1-339 (human)
8XBW - L=1-339 (human)
8YBJ - B/F=1-103 (human)
8YBK - B/F=1-103 (human)
8YJF - A=644-988 (human)
8YJM - A=644-988 (human)
8YTI - B/F/L/P=1-103 (human)
8YV8 - B/F=2-103 (human)
8Z50 - C=1-103 (human)
9EOZ - A=2-345 (human)
9FGQ - B/F=1-103 (human)
9FH9 - B/F=1-103 (human)
9IPU - K=1-147 (human)
1F66 - B/F=1-103 (mouse)
1U35 - B/F=1-103 (mouse)
2WP2 - P/Q=2-21 (mouse)
4AU7 - C=18-25 (mouse)
4DOW - C/D=15-26 (mouse)
