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HEC1
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. Belongs to the NDC80/HEC1 family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 17|17 E1.3 |
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Cellular Component:
centrosome; chromosome; chromosome, centromeric region; cytoplasm; kinetochore; Ndc80 complex; nucleoplasm; nucleus; outer kinetochore
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Molecular Function:
cyclin binding; identical protein binding; kinetochore adaptor activity; protein binding
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Biological Process:
attachment of mitotic spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore; cell cycle; cell division; centrosome duplication; chromosome segregation; establishment of mitotic spindle orientation; G2/MI transition of meiotic cell cycle; kinetochore organization; metaphase plate congression; mitotic cell cycle checkpoint signaling; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; mitotic spindle organization; positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of protein stability; skeletal muscle satellite cell proliferation; spindle assembly involved in female meiosis I
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Reference #:
Q9D0F1
(UniProtKB)
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Alt. Names/Synonyms: 2610020P18Rik; AV139730; HEC; Hec1; highly expressed in cancer, rich in leucine heptad repeats; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; Kntc; Kntc2; Ndc80; NDC80 homolog, kinetochore complex component; NDC80 homolog, kinetochore complex component (S. cerevisiae); NDC80 kinetochore complex component
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Gene Symbols: Ndc80
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Molecular weight:
73,962 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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