HEC1 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. Belongs to the NDC80/HEC1 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 18p11.32
Cellular Component:  centrosome; chromosome, centromeric region; cytosol; kinetochore; Ndc80 complex; nucleoplasm; nucleus; outer kinetochore
Molecular Function:  cyclin binding; identical protein binding; kinetochore adaptor activity; protein binding
Biological Process:  attachment of mitotic spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore; cell division; centrosome duplication; chromosome segregation; establishment of mitotic spindle orientation; G2/MI transition of meiotic cell cycle; kinetochore organization; metaphase plate congression; mitotic cell cycle; mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; mitotic spindle organization; positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of protein stability; skeletal muscle satellite cell proliferation; spindle assembly involved in female meiosis I
Reference #:  O14777 (UniProtKB)
Alt. Names/Synonyms: HEC; HEC1; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; KNTC2; NDC80; NDC80 homolog, kinetochore complex component; NDC80 homolog, kinetochore complex component (S. cerevisiae); NDC80 kinetochore complex component; NDC80 kinetochore complex component homolog; Retinoblastoma-associated protein HEC; TID3
Gene Symbols: NDC80
Molecular weight: 73,913 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Select Structure to View Below

HEC1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein