MED1 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells. Belongs to the Mediator complex subunit 1 family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  chromatin; mediator complex; nucleolus; nucleoplasm; nucleus; protein-DNA complex; ubiquitin ligase complex
Molecular Function:  chromatin binding; chromatin DNA binding; estrogen receptor binding; LBD domain binding; mediator complex binding; nuclear hormone receptor binding; nuclear receptor binding; nuclear receptor transcription coactivator activity; peroxisome proliferator activated receptor binding; protein binding; retinoic acid receptor binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; signaling receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription coregulator activity; transcription corepressor activity; transcription factor binding; ubiquitin protein ligase activity; vitamin D receptor binding
Biological Process:  androgen biosynthetic process; angiogenesis; animal organ regeneration; brain development; cell morphogenesis; cellular response to epidermal growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to steroid hormone stimulus; cellular response to thyroid hormone stimulus; embryonic heart tube development; embryonic hemopoiesis; embryonic hindlimb morphogenesis; embryonic placenta development; enucleate erythrocyte development; epithelial cell proliferation involved in mammary gland duct elongation; ERK1 and ERK2 cascade; erythrocyte development; fat cell differentiation; intracellular steroid hormone receptor signaling pathway; keratinocyte differentiation; lactation; lens development in camera-type eye; liver development; mammary gland branching involved in pregnancy; mammary gland branching involved in thelarche; megakaryocyte development; monocyte differentiation; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of erythrocyte differentiation; positive regulation of G0 to G1 transition; positive regulation of gene expression; positive regulation of hepatocyte proliferation; positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of signaling receptor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein import into nucleus; protein ubiquitination; regulation of cell cycle; regulation of lipid metabolic process; regulation of RNA biosynthetic process; regulation of transcription by RNA polymerase I; regulation of vitamin D receptor signaling pathway; retinal pigment epithelium development; thyroid hormone generation; thyroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter; ventricular trabecula myocardium morphogenesis
Reference #:  Q15648 (UniProtKB)
Alt. Names/Synonyms: Activator-recruited cofactor 205 kDa component; ARC205; CRSP1; CRSP200; DRIP205; DRIP230; MED1; Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1; MGC71488; p53 regulatory protein RB18A; PBP; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARBP; PPARG binding protein; PPARGBP; RB18A; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRAP220; TRIP-2; TRIP2; vitamin D receptor-interacting protein 230 kD; Vitamin D receptor-interacting protein complex component DRIP205
Gene Symbols: MED1
Molecular weight: 168,478 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA