syndecan-4 a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q42
Cellular Component:  cell surface; costamere; extracellular region; focal adhesion; integral component of membrane; membrane raft; plasma membrane
Molecular Function:  fibronectin binding; identical protein binding; protein binding; protein kinase C binding; thrombospondin receptor activity
Biological Process:  cell adhesion; cell migration; cell-cell signaling; inner ear receptor cell stereocilium organization; negative regulation of T cell proliferation; neural tube closure; positive regulation of exosomal secretion; positive regulation of extracellular exosome assembly; positive regulation of focal adhesion assembly; positive regulation of protein kinase activity; positive regulation of stress fiber assembly; regulation of fibroblast migration; ureteric bud development; wound healing
Reference #:  P34901 (UniProtKB)
Alt. Names/Synonyms: RATRYUDOCA; RYUDOCA; Ryudocan core protein; Ryudocan/syndecan 4; Sdc4; SYND4; syndecan 4; Syndecan-4
Gene Symbols: Sdc4
Molecular weight: 21,962 Da
Basal Isoelectric point: 4.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

syndecan-4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene