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PIP4K2B
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 10q31 |
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Cellular Component:
autophagosome; endoplasmic reticulum membrane; nucleoplasm; plasma membrane
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Molecular Function:
1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; protein homodimerization activity
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Biological Process:
phosphatidylinositol metabolic process; phosphatidylinositol phosphorylation; positive regulation of autophagosome assembly; regulation of autophagy
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Reference #:
O88377
(UniProtKB)
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Alt. Names/Synonyms: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; PIP4K2B
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Gene Symbols: Pip4k2b
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Molecular weight:
47,264 Da
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Basal Isoelectric point:
7.18
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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