PIP4K2B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 10q31
Cellular Component:  autophagosome; endoplasmic reticulum membrane; nucleoplasm; plasma membrane
Molecular Function:  1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; protein homodimerization activity
Biological Process:  phosphatidylinositol metabolic process; phosphatidylinositol phosphorylation; positive regulation of autophagosome assembly; regulation of autophagy
Reference #:  O88377 (UniProtKB)
Alt. Names/Synonyms: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; PIP4K2B
Gene Symbols: Pip4k2b
Molecular weight: 47,264 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PIP4K2B

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  Pfam  |  UniProtKB  |  Entrez-Gene