FABP2 FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Transporter
Chromosomal Location of rat Ortholog: 2q42
Cellular Component:  apical cortex; cytoplasm; cytosol; microvillus; nucleus; plasma membrane
Molecular Function:  fatty acid binding; long-chain fatty acid binding; long-chain fatty acid transporter activity
Biological Process:  fatty acid metabolic process; fatty acid transport; intestinal absorption; intestinal lipid absorption; long-chain fatty acid transport
Reference #:  P02693 (UniProtKB)
Alt. Names/Synonyms: FABP2; Fatty acid-binding protein, intestinal
Gene Symbols: Fabp2
Molecular weight: 15,124 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene