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CLIC1
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family. Expression is prominent in heart, placenta, liver, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Channel, chloride; Membrane protein, integral; Nuclear envelope |
| Chromosomal Location of rat Ortholog: 20p12 |
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Cellular Component:
chloride channel complex; cytoplasm; endoplasmic reticulum; extracellular exosome; membrane; mitochondrion; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
chloride channel activity; voltage-gated chloride channel activity; voltage-gated monoatomic ion channel activity
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Biological Process:
chloride transmembrane transport; chloride transport; platelet aggregation; positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of monoatomic ion transmembrane transport
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Reference #:
Q6MG61
(UniProtKB)
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Alt. Names/Synonyms: Chloride intracellular channel protein 1; CLIC1
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Gene Symbols: Clic1
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Molecular weight:
26,981 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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