HIP One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Belongs to the FAM10 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Chaperone
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  cytosol; protein-containing complex
Molecular Function:  chaperone binding; dATP binding; Hsp70 protein binding; identical protein binding; protein binding; protein dimerization activity; protein domain specific binding; protein-containing complex binding; unfolded protein binding
Biological Process:  chaperone cofactor-dependent protein refolding; negative regulation of protein refolding; protein homooligomerization; protein homotetramerization; response to bacterium
Reference #:  P50503 (UniProtKB)
Alt. Names/Synonyms: HIP; Hsc70-interacting protein
Gene Symbols: St13
Molecular weight: 41,280 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene