MSRA
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus. 5 human isoforms generated by alternative promoter usage, alternative splicing or alternative initiation have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 1.8.4.11; Mitochondrial; Oxidoreductase |
Chromosomal Location of rat Ortholog: 15p12 |
Cellular Component:
actin cytoskeleton; cytoplasm; cytosol; intracellular membrane-bounded organelle; midbody; mitochondrion; nucleoplasm; plasma membrane
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Molecular Function:
L-methionine-(S)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity
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Biological Process:
cellular response to oxidative stress
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Reference #:
Q923M1
(UniProtKB)
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Alt. Names/Synonyms: Mitochondrial peptide methionine sulfoxide reductase; MSRA
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Gene Symbols: Msra
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Molecular weight:
25,851 Da
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Basal Isoelectric point:
8.21
Predict pI for various phosphorylation states
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