MSRA Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Belongs to the MsrA Met sulfoxide reductase family. Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus. 5 human isoforms generated by alternative promoter usage, alternative splicing or alternative initiation have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.8.4.11; Mitochondrial; Oxidoreductase
Chromosomal Location of rat Ortholog: 15p12
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; intracellular membrane-bounded organelle; midbody; mitochondrion; nucleoplasm; plasma membrane
Molecular Function:  L-methionine-(S)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity
Biological Process:  cellular response to oxidative stress
Reference #:  Q923M1 (UniProtKB)
Alt. Names/Synonyms: Mitochondrial peptide methionine sulfoxide reductase; MSRA
Gene Symbols: Msra
Molecular weight: 25,851 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
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MSRA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene