ADK ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Belongs to the carbohydrate kinase PfkB family. Widely expressed. Highest level in placenta, liver, muscle and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 2.7.1.20; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of rat Ortholog: 15p16
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  adenosine kinase activity; ATP binding; metal ion binding
Biological Process:  adenosine metabolic process; AMP biosynthetic process; AMP salvage; circadian regulation of gene expression; dATP biosynthetic process; phosphorylation; positive regulation of cardiac muscle hypertrophy; positive regulation of T cell proliferation; purine ribonucleoside salvage; type B pancreatic cell proliferation
Reference #:  Q64640 (UniProtKB)
Alt. Names/Synonyms: Adenosine kinase; ADK
Gene Symbols: Adk
Molecular weight: 40,134 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
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ADK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  Pfam  |  UniProtKB  |  Entrez-Gene