EFTU Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; RNA-binding; Translation; Translation elongation
Chromosomal Location of Human Ortholog: 1q36
Cellular Component:  mitochondrial nucleoid; mitochondrion; synapse
Molecular Function:  GTP binding; GTPase activity; translation elongation factor activity
Biological Process:  mitochondrial translational elongation; response to ethanol; translational elongation
Reference #:  P85834 (UniProtKB)
Alt. Names/Synonyms: EFTU; Elongation factor Tu, mitochondrial; Tu translation elongation factor, mitochondrial; Tufm
Gene Symbols: Tufm
Molecular weight: 49,522 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
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EFTU

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein