|
AMSH
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Belongs to the peptidase M67C family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.1.2.15; EC 3.4.19.-; Protease; Ubiquitin-specific protease |
| Chromosomal Location of mouse Ortholog: 6|6 C3 |
|
Cellular Component:
cleavage furrow; cytoplasm; cytosol; endosome; membrane; nucleoplasm; nucleus; plasma membrane
|
|
Molecular Function:
deubiquitinase activity; hydrolase activity; K63-linked deubiquitinase activity; metal ion binding; metal-dependent deubiquitinase activity; metallopeptidase activity; peptidase activity; protein domain specific binding
|
|
Biological Process:
hippocampal neuron apoptotic process; mitotic cytokinesis; negative regulation of hippocampal neuron apoptotic process; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of Ras protein signal transduction; protein deubiquitination; protein K63-linked deubiquitination; proteolysis
|
|
Reference #:
Q9CQ26
(UniProtKB)
|
|
Alt. Names/Synonyms: 5330424L14Rik; 5730422L11Rik; Amsh; Associated molecule with the SH3 domain of STAM; AW107289; KIAA4198; mKIAA4198; STABP; STAM binding protein; STAM-binding protein; Stambp
|
|
Gene Symbols: Stambp
|
|
Molecular weight:
48,514 Da
|
|
Basal Isoelectric point:
6.2
Predict pI for various phosphorylation states
|
