AMSH Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Belongs to the peptidase M67C family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.15; EC 3.4.19.-; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 6|6 C3
Cellular Component:  cleavage furrow; cytoplasm; cytosol; endosome; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  hydrolase activity; Lys63-specific deubiquitinase activity; metal ion binding; metallopeptidase activity; peptidase activity; protein domain specific binding; thiol-dependent ubiquitin-specific protease activity
Biological Process:  mitotic cytokinesis; negative regulation of neuron apoptotic process; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of Ras protein signal transduction; protein deubiquitination; protein K63-linked deubiquitination; proteolysis
Reference #:  Q9CQ26 (UniProtKB)
Alt. Names/Synonyms: 5330424L14Rik; 5730422L11Rik; Amsh; Associated molecule with the SH3 domain of STAM; AW107289; KIAA4198; mKIAA4198; STABP; STAM binding protein; STAM-binding protein; Stambp
Gene Symbols: Stambp
Molecular weight: 48,514 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
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AMSH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene