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FBPase
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Belongs to the FBPase class 1 family. Expressed in pancreatic islets. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) |
| Chromosomal Location of rat Ortholog: 17p14 |
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Cellular Component:
cytoplasm; cytosol; extracellular space; nucleus
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Molecular Function:
AMP binding; fructose 1,6-bisphosphate 1-phosphatase activity; identical protein binding; metal ion binding; monosaccharide binding; RNA polymerase II-specific DNA-binding transcription factor binding
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Biological Process:
cellular hyperosmotic salinity response; cellular hypotonic salinity response; cellular response to cAMP; cellular response to insulin stimulus; cellular response to magnesium ion; cellular response to phorbol 13-acetate 12-myristate; cellular response to raffinose; cellular response to xenobiotic stimulus; dephosphorylation; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; fructose metabolic process; gluconeogenesis; negative regulation of cell growth; negative regulation of glycolytic process; negative regulation of Ras protein signal transduction; negative regulation of transcription by RNA polymerase II; regulation of gluconeogenesis; response to nutrient levels; sucrose biosynthetic process
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Reference #:
P19112
(UniProtKB)
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Alt. Names/Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Fbp; Fbp1; FBPase; FBPase 1; Fdp; fructose-1,6- biphosphatase 1; Fructose-1,6-bisphosphatase 1; Fructose-16- biphosphatase
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Gene Symbols: Fbp1
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Molecular weight:
39,609 Da
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Basal Isoelectric point:
5.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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