CDC42 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis

Chromosomal Location of human Ortholog: 1p36.12

Cellular Component: apical part of cell; cell-cell junction; centrosome; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendritic spine; endoplasmic reticulum membrane; filopodium; glutamatergic synapse; Golgi membrane; Golgi transport complex; leading edge membrane; membrane; midbody; mitotic spindle; neuron projection; neuronal cell body; phagocytic vesicle; plasma membrane; protein-containing complex; spindle midzone; storage vacuole

Molecular Function: apolipoprotein A-I receptor binding; G protein activity; GBD domain binding; GTP binding; GTP-dependent protein binding; GTPase activity; identical protein binding; protein binding; protein kinase binding; thioesterase binding; ubiquitin protein ligase activity

Biological Process: actin cytoskeleton organization; actin filament organization; adherens junction organization; cardiac conduction system development; cardiac neural crest cell migration involved in outflow tract morphogenesis; Cdc42 protein signal transduction; cell junction assembly; cellular response to type II interferon; dendritic cell migration; dendritic spine morphogenesis; embryonic heart tube development; endocytosis; endothelin receptor signaling pathway involved in heart process; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; establishment or maintenance of cell polarity; filopodium assembly; Golgi organization; heart contraction; integrin-mediated signaling pathway; macrophage differentiation; modification of synaptic structure; modulation by host of viral process; negative regulation of protein-containing complex assembly; neuron fate determination; neuropilin signaling pathway; nuclear migration; organelle transport along microtubule; phagocytosis, engulfment; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cytokinesis; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of lamellipodium assembly; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pinocytosis; positive regulation of pseudopodium assembly; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; protein localization; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; regulation of lamellipodium assembly; regulation of mitotic nuclear division; regulation of postsynapse organization; regulation of protein binding; regulation of stress fiber assembly; Wnt signaling pathway, planar cell polarity pathway

Reference #: P60953 (UniProtKB)

Alt. Names/Synonyms: CDC42; CDC42Hs; Cell division control protein 42 homolog; cell division cycle 42; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein, 25kD; small GTP binding protein CDC42; TKS

Gene Symbols: CDC42

Molecular weight: 21,259 Da

Basal Isoelectric point: 6.16 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

Select Structure to View Below
CDC42

Get PyMOL Script Get Chimera Script