SELL Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. Expressed in B-cell lines and T-lymphocytes. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component:  integral component of plasma membrane; plasma membrane; secretory granule membrane
Molecular Function:  calcium ion binding; carbohydrate binding; glycosphingolipid binding; heparin binding; oligosaccharide binding; protease binding; protein binding
Biological Process:  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; leukocyte migration; leukocyte tethering or rolling; neutrophil degranulation; regulation of immune response
Disease: Iga Nephropathy, Susceptibility To, 1
Reference #:  P14151 (UniProtKB)
Alt. Names/Synonyms: CD62 antigen-like family member L; CD62L; gp90-MEL; L-selectin; LAM-1; LAM1; LECAM1; LEU8; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; LYAM1; Lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor; PLNHR; selectin L; SELL; TQ1
Gene Symbols: SELL
Molecular weight: 42,187 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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