14-3-3 beta a protein of the 14-3-3 family of proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Belongs to the 14-3-3 family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  cytoplasm; cytosol; perinuclear region of cytoplasm; protein-containing complex; transcription repressor complex
Molecular Function:  enzyme binding; histone deacetylase binding; identical protein binding; phosphoprotein binding; phosphoserine residue binding; protein binding; protein domain specific binding; protein kinase inhibitor activity; protein-containing complex binding
Biological Process:  cytoplasmic sequestering of protein; negative regulation of DNA-templated transcription; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of protein dephosphorylation; positive regulation of catalytic activity; protein targeting; signal transduction
Reference #:  Q9CQV8 (UniProtKB)
Alt. Names/Synonyms: 1300003C17Rik; 14-3-3 beta; 14-3-3 protein beta; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 14-3-3b; 1433B; KCIP-1; OTTMUSP00000017275; Protein kinase C inhibitor protein 1; RP23-321M14.1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; Ywhab
Gene Symbols: Ywhab
Molecular weight: 28,086 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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14-3-3 beta

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene