EXOSC4 Non-catalytic component of the RNA exosome complex which has 3'- Belongs to the RNase PH family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.13.-; Nucleolus; Ribonuclease
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  cytoplasm; cytosol; exosome (RNase complex); intermediate filament cytoskeleton; nucleolus; nucleoplasm; nucleus; transcriptionally active chromatin
Molecular Function:  3'-5'-exoribonuclease activity; mRNA 3'-UTR AU-rich region binding; protein binding
Biological Process:  defense response to virus; DNA deamination; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; histone mRNA catabolic process; maturation of 5.8S rRNA; nuclear mRNA surveillance; nuclear-transcribed mRNA catabolic process; positive regulation of cell growth; regulation of mRNA stability; RNA phosphodiester bond hydrolysis, exonucleolytic; rRNA processing
Reference #:  Q9NPD3 (UniProtKB)
Alt. Names/Synonyms: EXOS4; EXOSC4; Exosome complex component RRP41; Exosome complex exonuclease RRP41; Exosome component 4; exosome component Rrp41; FLJ20591; hRrp41p; p12A; Ribosomal RNA-processing protein 41; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Gene Symbols: EXOSC4
Molecular weight: 26,383 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene