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TRAPPC6B
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival. Belongs to the TRAPP small subunits family. BET3 subfamily. Both isoforms are expressed ubiquitously (at transcript level), isoform 1 being the most predominant (PubMed:28626029). Expressed in the fetal brain and different regions of the adult brain and spinal cord (PubMed:28626029). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 14q21.1 |
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Cellular Component:
cis-Golgi network; cytoplasm; cytosol; endoplasmic reticulum; trans-Golgi network; TRAPP complex; TRAPPII protein complex
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Molecular Function:
protein binding
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Biological Process:
endoplasmic reticulum to Golgi vesicle-mediated transport; nervous system development; regulation of GTPase activity; vesicle coating; vesicle tethering
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Disease: Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Brain Atrophy
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Reference #:
Q86SZ2
(UniProtKB)
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Alt. Names/Synonyms: FLJ17772; FLJ79549; NEDMEBA; TPC6; TPC6B; trafficking protein particle complex 6B; Trafficking protein particle complex subunit 6B; TRAPP complex subunit 6B; TRAPPC6B
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Gene Symbols: TRAPPC6B
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Molecular weight:
17,983 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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