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AQP2
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Belongs to the MIP/aquaporin (TC 1.A.8) family. Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718). Note: This description may include information from UniProtKB.
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| Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family |
| Chromosomal Location of mouse Ortholog: 15 F1|15 56.13 cM |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; early endosome; endosome membrane; exocytic vesicle; extracellular exosome; Golgi apparatus; lumenal side of membrane; membrane; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; recycling endosome; recycling endosome membrane; trans-Golgi network
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Molecular Function:
actin binding; channel activity; glycerol transmembrane transporter activity; PDZ domain binding; water channel activity; water transmembrane transporter activity
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Biological Process:
actin filament depolymerization; cell volume homeostasis; cellular response to copper ion; cellular response to mercury ion; cellular response to water deprivation; glycerol transmembrane transport; metanephric collecting duct development; positive regulation of calcium ion transport; protein homotetramerization; renal water homeostasis; renal water transport; transmembrane transport; water transport
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Reference #:
P56402
(UniProtKB)
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Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; Aqp2; aquaporin 2; Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; cph; jpk; Water channel protein for renal collecting duct; WCH-CD
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Gene Symbols: Aqp2
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Molecular weight:
28,965 Da
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Basal Isoelectric point:
6.44
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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