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AQP2
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Belongs to the MIP/aquaporin (TC 1.A.8) family. Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718). Note: This description may include information from UniProtKB.
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| Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family |
| Chromosomal Location of Human Ortholog: 12q13.12 |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; extracellular exosome; Golgi apparatus; integral component of plasma membrane; membrane; plasma membrane; recycling endosome; transport vesicle membrane
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Molecular Function:
glycerol transmembrane transporter activity; protein binding; water channel activity; water transmembrane transporter activity
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Biological Process:
cellular response to copper ion; cellular response to mercury ion; cellular response to water deprivation; glycerol transport; metanephric collecting duct development; protein homotetramerization; renal water homeostasis; renal water transport; transmembrane transport; water transport
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Disease: Diabetes Insipidus, Nephrogenic, Autosomal
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Reference #:
P41181
(UniProtKB)
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Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; AQP2; aquaporin 2; aquaporin 2 (collecting duct); Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD
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Gene Symbols: AQP2
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Molecular weight:
28,837 Da
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Basal Isoelectric point:
6.44
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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