AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. Belongs to the MIP/aquaporin (TC 1.A.8) family. Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718). Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 7q36
Cellular Component:  apical plasma membrane; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; early endosome; exocytic vesicle; extracellular exosome; integral component of membrane; integral component of plasma membrane; lysosome; membrane; plasma membrane; pore complex; protein-containing complex; recycling endosome; rough endoplasmic reticulum; trans-Golgi network; transport vesicle
Molecular Function:  actin binding; glycerol transmembrane transporter activity; PDZ domain binding; porin activity; protein binding; water channel activity; water transmembrane transporter activity
Biological Process:  actin filament depolymerization; aging; apoptotic process; cell volume homeostasis; cellular response to copper ion; cellular response to mercury ion; cellular response to water deprivation; female pregnancy; glycerol transport; hyperosmotic response; metanephric collecting duct development; positive regulation of calcium ion transport; protein homotetramerization; renal water homeostasis; renal water transport; response to calcium ion; response to glucagon; response to hormone; response to lipopolysaccharide; response to lithium ion; response to salt stress; response to starvation; response to water deprivation; transmembrane transport; water homeostasis; water transport
Reference #:  P34080 (UniProtKB)
Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; Aqp2; aquaporin 2 (collecting duct); Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; MGC156502; Water channel protein for renal collecting duct; WCH-CD
Gene Symbols: Aqp2
Molecular weight: 28,931 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene