14-3-3 zeta Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: 
Reference #:  P29361 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 protein zeta/delta; 1433Z; 143Z; Factor activating exoenzyme S; FAS; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta; YWHAZ
Gene Symbols: YWHAZ
Molecular weight: 27,856 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 zeta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene