AGA Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Belongs to the Ntn-hydrolase family. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - other glycan degradation; Hydrolase
Chromosomal Location of Human Ortholog: 4q34.3
Cellular Component:  azurophil granule lumen; endoplasmic reticulum; extracellular region; extracellular space; lysosome
Molecular Function:  N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; peptidase activity; protein self-association
Biological Process:  neutrophil degranulation; protein deglycosylation; proteolysis
Disease: Aspartylglucosaminuria
Reference #:  P20933 (UniProtKB)
Alt. Names/Synonyms: AGA; AGU; Aspartylglucosaminidase; aspartylglucosylamine deaspartylase; ASPG; ASRG; GA; Glycosylasparaginase; Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
Gene Symbols: AGA
Molecular weight: 37,208 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein