ASGP-R
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Expressed exclusively in hepatic parenchymal cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Receptor, misc. |
Chromosomal Location of rat Ortholog: 10q24 |
Cellular Component:
endoplasmic reticulum quality control compartment; external side of plasma membrane; membrane; perinuclear region of cytoplasm
|
Molecular Function:
fucose binding; mannose binding
|
Biological Process:
biological process involved in interspecies interaction between organisms; bone mineralization; endocytosis; glycoprotein metabolic process; lipid homeostasis; regulation of protein stability
|
Reference #:
P08290
(UniProtKB)
|
Alt. Names/Synonyms: ASGP-R; ASGP-R 2; ASGPR 2; Asgr-2; Asgr2; Asialoglycoprotein receptor 2; hepatic lectin 2 RHL2; hepatic lectin 2, RHL2; Hepatic lectin R2/3; HL-2; MGC108546; rHL-2
|
Gene Symbols: Asgr2
|
Molecular weight:
35,027 Da
|
Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
|