ASGP-R Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Expressed exclusively in hepatic parenchymal cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  endoplasmic reticulum quality control compartment; integral component of membrane; perinuclear region of cytoplasm
Molecular Function:  carbohydrate binding
Biological Process:  bone mineralization; endocytosis; glycoprotein metabolic process; lipid homeostasis; regulation of protein stability
Reference #:  P08290 (UniProtKB)
Alt. Names/Synonyms: ASGP-R; ASGP-R 2; ASGPR 2; Asgr-2; Asgr2; Asialoglycoprotein receptor 2; hepatic lectin 2 RHL2; hepatic lectin 2, RHL2; Hepatic lectin R2/3; HL-2; MGC108546; rHL-2
Gene Symbols: Asgr2
Molecular weight: 35,027 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene