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CUL4A
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1. With CUL4B, contributes to ribosome biogenesis. Belongs to the cullin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of rat Ortholog: 16q12.5 |
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Cellular Component:
Cul4-RING E3 ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; nucleus
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Molecular Function:
ubiquitin ligase complex scaffold activity; ubiquitin protein ligase activity; ubiquitin protein ligase binding
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Biological Process:
cell population proliferation; cellular response to UV; DNA damage response; hemopoiesis; in utero embryonic development; negative regulation of granulocyte differentiation; positive regulation of cell population proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of DNA damage checkpoint; regulation of nucleotide-excision repair; regulation of protein metabolic process; ribosome biogenesis; somatic stem cell population maintenance; spermatogenesis; T cell activation; ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Reference #:
B2RYJ3
(UniProtKB)
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Alt. Names/Synonyms: Cul4a; Cullin 4A; RGD1563853
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Gene Symbols: Cul4a
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Molecular weight:
87,774 Da
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Basal Isoelectric point:
8.53
Predict pI for various phosphorylation states
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