ASGP-R Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Expressed exclusively in hepatic parenchymal cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  endoplasmic reticulum quality control compartment; integral component of membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  asialoglycoprotein receptor activity; carbohydrate binding; protein binding
Biological Process:  bone mineralization; cell surface receptor signaling pathway; endocytosis; lipid homeostasis; protein N-linked glycosylation via asparagine; regulation of protein stability; viral process
Reference #:  P07307 (UniProtKB)
Alt. Names/Synonyms: ASGP-R; ASGP-R 2; ASGP-R2; ASGPR 2; ASGPR2; ASGR2; Asialoglycoprotein receptor 2; asialoglycoprotein receptor H2; C-type lectin domain family 4 member H2; C-type lectin domain family 4, member H2; CLEC4H2; HBxAg-binding protein; HBXBP; Hepatic lectin H2; HL-2; Hs.1259; L-H2
Gene Symbols: ASGR2
Molecular weight: 35,092 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein