ASGP-R cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  endoplasmic reticulum quality control compartment; integral component of membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  asialoglycoprotein receptor activity; carbohydrate binding; protein binding
Biological Process:  bone mineralization; cell surface receptor signaling pathway; endocytosis; lipid homeostasis; protein N-linked glycosylation via asparagine; regulation of protein stability; viral process
Reference #:  P07307 (UniProtKB)
Alt. Names/Synonyms: ASGP-R; ASGP-R 2; ASGPR 2; ASGR2; Asialoglycoprotein receptor 2; asialoglycoprotein receptor H2; C-type lectin domain family 4 member H2; C-type lectin domain family 4, member H2; CLEC4H2; Hepatic lectin H2; HL-2; Hs.1259; L-H2
Gene Symbols: ASGR2
Molecular weight: 35,092 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
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ASGP-R

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein