AMOTL1 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Belongs to the angiomotin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of rat Ortholog: 8q12
Cellular Component:  apical plasma membrane; bicellular tight junction; cytoplasmic vesicle; lamellipodium
Molecular Function:  identical protein binding
Biological Process:  actin cytoskeleton organization; angiogenesis; establishment of cell polarity involved in ameboidal cell migration; hippo signaling; positive regulation of blood vessel endothelial cell migration; regulation of cell migration
Reference #:  F1LZQ6 (UniProtKB)
Alt. Names/Synonyms: Amotl1; Angiomotin-like 1; RGD1305268
Gene Symbols: Amotl1
Molecular weight: 81,499 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein