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AMSH
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Belongs to the peptidase M67C family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.2.15; EC 3.4.19.-; Protease; Ubiquitin-specific protease |
| Chromosomal Location of rat Ortholog: 4q34 |
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Cellular Component:
cleavage furrow; cytosol; early endosome; endosome; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
deubiquitinase activity; K63-linked deubiquitinase activity; metal ion binding; metal-dependent deubiquitinase activity; protein domain specific binding
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Biological Process:
hippocampal neuron apoptotic process; mitotic cytokinesis; negative regulation of hippocampal neuron apoptotic process; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of Ras protein signal transduction; protein deubiquitination; protein K63-linked deubiquitination
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Reference #:
Q8R424
(UniProtKB)
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Alt. Names/Synonyms: Amsh; Associated molecule with the SH3 domain of STAM; STABP; Stam binding protein; STAM-binding protein; Stambp
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Gene Symbols: Stambp
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Molecular weight:
48,512 Da
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Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
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