AMSH Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Belongs to the peptidase M67C family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.15; EC 3.4.19.-; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component:  cleavage furrow; cytosol; early endosome; nucleoplasm; nucleus; plasma membrane
Molecular Function:  metal ion binding; metallopeptidase activity; protein binding; protein domain specific binding; thiol-dependent ubiquitin-specific protease activity
Biological Process:  JAK-STAT cascade; mitotic cytokinesis; negative regulation of neuron apoptotic process; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination
Disease: Microcephaly-capillary Malformation Syndrome
Reference #:  O95630 (UniProtKB)
Alt. Names/Synonyms: AMSH; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; STABP; STAM binding protein; STAM-binding protein; STAMBP
Gene Symbols: STAMBP
Molecular weight: 48,077 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AMSH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein