14-3-3 beta a protein of the 14-3-3 family of proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Belongs to the 14-3-3 family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component:  cytoplasm; cytosol; melanosome; mitochondrion; nucleus; perinuclear region of cytoplasm; transcriptional repressor complex; vacuolar membrane
Molecular Function:  enzyme binding; histone deacetylase binding; identical protein binding; phosphoprotein binding; phosphoserine residue binding; protein binding; protein C-terminus binding; protein domain specific binding; protein-containing complex binding
Biological Process:  cytoplasmic sequestering of protein; hippo signaling; MAPK cascade; membrane organization; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of protein dephosphorylation; negative regulation of transcription, DNA-templated; positive regulation of catalytic activity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein heterooligomerization; protein targeting; regulation of mRNA stability; viral process
Reference #:  P31946 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 alpha; 14-3-3 beta; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 1433B; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; GW128; HEL-S-1; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; YWHAA; YWHAB
Gene Symbols: YWHAB
Molecular weight: 28,082 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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14-3-3 beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene