14-3-3 beta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component:  cytoplasm; cytosol; melanosome; mitochondrion; nucleus; perinuclear region of cytoplasm; transcriptional repressor complex; vacuolar membrane
Molecular Function:  enzyme binding; histone deacetylase binding; identical protein binding; phosphoprotein binding; phosphoserine residue binding; protein binding; protein C-terminus binding; protein domain specific binding; protein-containing complex binding
Biological Process:  cytoplasmic sequestering of protein; hippo signaling; MAPK cascade; membrane organization; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of protein dephosphorylation; negative regulation of transcription, DNA-templated; positive regulation of catalytic activity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein heterooligomerization; protein targeting; regulation of mRNA stability; viral process
Reference #:  P31946 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 1433B; brain protein 14-3-3, beta isoform; GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; YWHAB
Gene Symbols: YWHAB
Molecular weight: 28,082 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene