AMPKG1 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Autophagy; Protein kinase, regulatory subunit

Chromosomal Location of human Ortholog: 12q13.12

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleotide-activated protein kinase complex; nucleus

Molecular Function: ADP binding; AMP binding; ATP binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; protein binding; protein kinase activity; protein kinase binding; protein kinase regulator activity

Biological Process: cellular response to nutrient levels; fatty acid biosynthetic process; import into nucleus; positive regulation of gene expression; positive regulation of protein kinase activity; protein phosphorylation; regulation of catalytic activity; regulation of glycolytic process; signal transduction; spermatogenesis

Reference #: P54619 (UniProtKB)

Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, gamma-1 subunit; AAKG1; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; AMPKG1; MGC8666; PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit

Gene Symbols: PRKAG1

Molecular weight: 37,579 Da

Basal Isoelectric point: 6.42 Predict pI for various phosphorylation states

CST Pathways: AMPK Signaling

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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AMPKG1

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