AMPKG1 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 7q36
Cellular Component:  cytosol; nucleotide-activated protein kinase complex; nucleus; protein-containing complex
Molecular Function:  adenyl ribonucleotide binding; ADP binding; AMP binding; ATP binding; protein binding; protein kinase activity; protein kinase binding
Biological Process:  fatty acid biosynthetic process; import into nucleus; positive regulation of gene expression; protein heterooligomerization; protein phosphorylation; regulation of catalytic activity; regulation of protein serine/threonine kinase activity
Reference #:  P80385 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-1; AAKG1; AMP-activated protein kinase, noncatalytic gamma-1 subunit; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; AMPKG1; Prkaac; Prkag1; Prkga1; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Gene Symbols: Prkag1
Molecular weight: 37,386 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene