SLC17A1 Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. Expressed in kidney cortex, liver and brain but not in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component:  apical plasma membrane; membrane; plasma membrane
Molecular Function:  sodium-dependent phosphate transmembrane transporter activity; symporter activity
Biological Process:  ion transport; phosphate ion transmembrane transport; phosphate ion transport; sodium ion transport; sodium-dependent phosphate transport; urate metabolic process; urate transport
Reference #:  Q14916 (UniProtKB)
Alt. Names/Synonyms: MGC126794; MGC126796; Na(+)/PI cotransporter 1; Na/Pi-4; NAPI-1; NPT-1; NPT1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; SLC17A1; sodium phosphate transporter; Sodium-dependent phosphate transport protein 1; Sodium/phosphate cotransporter 1; sodium/phosphate type I cotransporter; solute carrier family 17 (sodium phosphate), member 1; solute carrier family 17 (vesicular glutamate transporter), member 1; Solute carrier family 17 member 1
Gene Symbols: SLC17A1
Molecular weight: 51,132 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene