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SYN2
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons. Belongs to the synapsin family. Central and peripheral nervous systems. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of Human Ortholog: 4q42 |
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Cellular Component:
cell junction; extrinsic component of synaptic vesicle membrane; glutamatergic synapse; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
ATP binding; calcium-dependent protein binding; cytoskeletal protein binding; protein binding
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Biological Process:
calcium ion regulated exocytosis; neurotransmitter secretion; regulation of neurotransmitter secretion; synaptic vesicle clustering; synaptic vesicle cycle
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Reference #:
Q63537
(UniProtKB)
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Alt. Names/Synonyms: Syn2; synapsin 2; Synapsin II; Synapsin-2
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Gene Symbols: Syn2
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Molecular weight:
63,457 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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