SYN2 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons. Belongs to the synapsin family. Central and peripheral nervous systems. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of rat Ortholog: 4q42
Cellular Component:  extrinsic component of synaptic vesicle membrane; glutamatergic synapse; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function:  ATP binding; calcium-dependent protein binding; cytoskeletal protein binding; identical protein binding; protein binding
Biological Process:  calcium-ion regulated exocytosis; neurotransmitter secretion; regulation of neurotransmitter secretion; synaptic vesicle clustering; synaptic vesicle cycle
Reference #:  Q63537 (UniProtKB)
Alt. Names/Synonyms: Syn2; synapsin 2; Synapsin II; Synapsin-2
Gene Symbols: Syn2
Molecular weight: 63,457 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene