PYGM Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - starch and sucrose; EC; Endoplasmic reticulum; Phosphorylase; Transferase
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  cytoplasm; sarcoplasmic reticulum
Molecular Function:  AMP binding; carbohydrate binding; drug binding; glycogen phosphorylase activity; linear malto-oligosaccharide phosphorylase activity; protein homodimerization activity; pyridoxal phosphate binding; SHG alpha-glucan phosphorylase activity
Biological Process:  cellular calcium ion homeostasis; glycogen catabolic process; glycogen metabolic process; response to cAMP; response to hypoxia; response to organic substance
Reference #:  P09812 (UniProtKB)
Alt. Names/Synonyms: Glycogen phosphorylase, muscle form; muscle (McArdle syndrome); muscle glycogen phosphorylase; Muscpho; Myophosphorylase; Phosphorylase, glycogen; phosphorylase, glycogen, muscle; Pygm
Gene Symbols: Pygm
Molecular weight: 97,273 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene